Best Anti-Inflammatory Supplements 2026 | CRP Evidence Ranked

Chronic low-grade inflammation — measured by C-reactive protein (CRP) and IL-6 — underlies most chronic disease. These 6 compounds have the strongest RCT evidence for reducing inflammatory biomarkers.

1. Omega-3 EPA+DHA — Score 9.5/10

Meta-analysis of 18 RCTs: 2,000–3,000mg EPA/day reduces CRP by 33% and IL-6 by 22%. The most evidence-backed anti-inflammatory supplement available OTC. Full review

2. Curcumin + Piperine — Score 9.0/10

Inhibits NF-κB — the master inflammation regulator. A 2021 meta-analysis (n=1,253) showed -6.4 mg/L CRP vs placebo. Full review

3. Magnesium Glycinate — Score 9.6/10

Addressing magnesium deficiency removes a chronic inflammatory driver. Also reduces cortisol and supports sleep. Full review

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