Longevity research has accelerated dramatically since 2020. For the first time, scientists can point to specific molecular pathways that drive aging — and compounds that intervene. Here’s what the researchers themselves take.
The Longevity Scientists’ Stack
NMN — David Sinclair (Harvard)
8.5/10
Sinclair takes 1g NMN + 1g resveratrol daily. NMN raises NAD+ which activates sirtuins — the longevity genes that repair DNA and regulate metabolism. NAD+ drops 50% between age 40-60. Protocol: 250-500mg sublingual each morning.
Berberine — Metabolic Longevity
9.2/10
Activates AMPK — the same pathway as caloric restriction and exercise. Animal studies show 30-40% lifespan extension. Human data shows significant improvement in metabolic biomarkers associated with longevity. Protocol: 500mg 3x daily.
Taurine — 2023 Science Breakthrough
8.7/10
A 2023 paper in Science found taurine supplementation extended healthy lifespan 10-12% in mice, and improved multiple aging markers in primates. Taurine declines 80% from youth to old age. One of the most promising longevity discoveries. Protocol: 2g/day.
Omega-3 — Brain & Cardiovascular
9.5/10
People with higher DHA levels have larger brain volume at age 70+. High EPA reduces all-cause mortality. Omega-3 index above 8% is associated with dramatically lower cardiovascular and cognitive decline risk. Protocol: 2-4g EPA+DHA rTG daily.
Vitamin D3+K2 — Foundation
9.4/10
Vitamin D deficiency accelerates telomere shortening (aging biomarker) and is associated with 80% higher all-cause mortality risk at severe deficiency. Target 60-80 ng/mL. K2 prevents vascular calcification. Protocol: 5000IU D3 + 100mcg K2.
The Complete Longevity Stack
Top Rated Supplements
NMN8.5/10Apigenin8.6/10Taurine8.7/10
All reviews include price comparisons & third-party testing verification
Get the Full 2026 Supplement Dosing Guide
Free — exact doses, forms, and timing for 14 supplements. PubMed-backed.
NordVital Research Team
Evidence-Based Health Research
Our editorial team reviews and fact-checks all supplement content against peer-reviewed research. We follow strict editorial guidelines and only recommend products that meet our evidence standards. Learn about our process →