Omega-3 Dosage Guide (2026): How Much EPA+DHA Do You Actually Need?
Most omega-3 supplements label total fish oil content — not EPA+DHA content. A “1,000mg fish oil” capsule may contain only 300mg of combined EPA+DHA. Dose to EPA+DHA content, not to fish oil weight.
Dose by Goal
| Goal | Daily EPA+DHA Dose | Key RCT |
|---|---|---|
| General health maintenance | 500–1,000mg | AHA guidelines |
| Cardiovascular risk reduction | 1,000–2,000mg EPA | REDUCE-IT (4g/day icosapentaenoic acid) |
| Anti-inflammatory / joint pain | 2,000–3,000mg | AJCN 2020 meta-analysis |
| Depression / mood support | 1,000–2,000mg EPA | Meta-analysis (26 RCTs, n=1,546) |
| Triglyceride reduction | 3,000–4,000mg | AHA prescription dose (Vascepa) |
rTG vs Ethyl Ester: Why Form Matters
Triglyceride (TG) and re-esterified triglyceride (rTG) forms absorb 70% better than ethyl ester (EE) forms. Most cheap fish oils are ethyl ester. If you’re dosing at 1,000mg EPA+DHA in EE form, you’re likely absorbing ~650mg. In rTG form, absorption is close to 100%. Pay more for rTG — or compensate with higher EE doses.
Related: Omega-3 Supplement Review | Fish Oil vs Krill Oil
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