Andrew Huberman Supplement Stack: Complete 2025 Protocol

Based on Huberman Lab Podcast Episodes · Updated 2025

Andrew Huberman’s Supplement Protocol (From His Podcast)

Dr. Andrew Huberman, neuroscientist and host of the Huberman Lab podcast at Stanford, is one of the most referenced voices in evidence-based supplement use. His protocols are detailed in multiple podcast episodes and have been compiled here with the clinical evidence for each supplement.

Foundation Supplements (Daily)

AG1 (Athletic Greens): Huberman’s primary sponsor — comprehensive greens, vitamins, minerals, probiotics. Takes 1 serving/day. Note: available at aggressive prices through his affiliate link; comparable alternatives exist at lower cost.

Vitamin D3 5,000 IU + Vitamin K2 100mcg: For immune function, bone density, and testosterone support. Taken with breakfast (fat-soluble). Evidence: multiple RCTs supporting D3+K2 combination.

Omega-3 fish oil 2-4g EPA+DHA: For cardiovascular health, brain function, and anti-inflammation. Huberman emphasizes rTG form. Takes with meals.

Sleep Stack

Magnesium L-threonate 145mg + Magnesium bisglycinate 200mg: For sleep quality and brain magnesium levels. Taken 30-60 min before bed.

Apigenin 50mg: Natural GABA-A agonist and CD38 inhibitor. “The chamomile derivative that acts as a gentle sedative.” Taken at bedtime.

L-theanine 100-200mg: For sleep onset and quality. Not used every night — Huberman cycles off periodically. May cause vivid dreams at higher doses.

Focus and Cognitive Performance Stack

Alpha-GPC 300mg: Pre-workout or pre-focus-work. Raises acetylcholine. Huberman mentions 10-30 min pre-training. Cycles off 1-2x/week to prevent TMAO accumulation concerns.

Tyrosine 500mg: Dopamine and norepinephrine precursor. Pre-demanding tasks. Not taken with caffeine as the combined stimulant effect can cause anxiety.

Testosterone and Longevity Stack

Ashwagandha KSM-66 300mg: Cortisol reduction, testosterone support. Huberman cycles on/off — 2 weeks on, 1-2 weeks off, or 8 weeks on/4 off.

NMN 500-1000mg sublingual: NAD+ precursor for longevity. Taken in the morning fasted. Combined with resveratrol 1g (with fat) for SIRT1 activation.

Tongkat ali 400mg: Free testosterone support. Huberman has mentioned using this in multiple episodes, noting it increases free testosterone and reduces SHBG.

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